姓 名：石磊
个人简介
教育背景
2001.09—2005.07 上海交通大学 学士学位
2005.09—2010.07 中国科学院生物物理研究所 博士学位
工作经历
2010.07—2012.07 重庆老员工命科学研究院 讲师
2012.07—2017.09 太阳成集团tyc7111cc 讲师
2017.09— 太阳成集团tyc7111cc 副教授
研究领域
研究原核生物免疫系统及其与机体免疫系统的互作关系。
学术兼职
重庆市生物化学与分子生物学学会理事
科研项目
主持国家自然基金青年项目1项，教育部博士点新教师基金1项，中央高校科研业务经费面上项目1项。
代表性论文
Zhang J, Huang X, Hou Y, Xia X, Zhu Z, Huang A, Feng S, Li P, Shi L*, Dong P*. Isolation and Screening of Antagonistic Endophytes against Phytophthora infestans and Preliminary Exploration on Anti-oomycete Mechanism of Bacillus velezensis 6-5. Plants. 2023; 12(4):909. (*Corresponding author)
Li M, Kaili D, Shi L*. Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers. World J Gastrointest Oncol. 2022 Jan 15;14(1):19-37. (*Corresponding author)
Shi L, Liu Y, Li M, Luo Z. Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity. FEBS J. 2021 May 27.
Huang R, Zhou L, Chi Y, Wu H, Shi L*. LncRNA profile study reveals a seven-lncRNA signature predicts the prognosis of patients with colorectal cancer. Biomark Res. 2020 Feb 28;8:8. (*Corresponding author)
Qian Y, Shi L*, Luo Z*. Long Non-coding RNAs in Cancer: Implications for Diagnosis, Prognosis, and Therapy. Front Med (Lausanne). 2020 Nov 30;7:612393. (*Corresponding author)
Zhao Z, Zhang C, Zhou L, Dong P*, Shi L*. Neurotoxicities associated with immune checkpoint inhibitor therapy. Curr Neuropharmacol. 2020 Dec 30. (*Corresponding author)
Shi, L.*, Yu, L., Zou, F., Hu, H., Liu, K., & Lin, Z.* (2017). Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmospheric plasma-activated medium. Peerj, 5:e3751. *Corresponding author
Shi L*, Zhang W, Zou F, Mei L, Wu G, Teng Y*. KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma. BMC Cancer. 2016 Oct 21;16(1):815. *Corresponding author
Shi L, Wu L, Wang S, Fan Z. Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation. Cell Death and Differentiation 2009 Dec;16(12):1694-706.
Zhang H, Zhong C, Shi L, Guo Y, Fan Z. Granulysin induces cathepsin B release of lysosomes of target tumor cells to target mitochondria through processing of Bid. Journal of Immunology 2009; 182(11):6993-7000.
D Hu, S Liu, L Shi, L Wu, C Li, Z Fan. Cleavage of survivin by Granzyme M triggers degradation of the survivin-XIAP complex to free caspase activity leading to cytolysis of target tumor cells. Journal of Biological Chemistry 2010 Jun 11;285(24):18326-35.
Guo Y*, Chen J*, Shi L, Fan Z. Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. Journal of Immunology 2010; 185(9):5348-59. (*equal contribution)
Wang S, Xia P, Shi L, Fan Z. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. Cell Death and Differentiation 2011; 19(4): p.605-15.
Shi, GQ, QY Yu, L Shi, Z Zhang*. Molecular cloning and characterization of peroxiredoxin 4 involved in protection against oxidative stress in the silkworm Bombyx mori. Insect Mol Biol 2012; 21: 581-92
开设课程
本科生：
细胞生物学
研究生：
功能基因组学
